Figure 4: Schematic signaling by Type I nuclear receptors (such as the estrogen receptor - on the left) and Type II nuclear receptors (such as thyroid hormone receptor - on the right), depicted as a Molecular Interaction Map. Syntactic rules of the MIM are depicted in Fig. 2. The red cartouche represent the molecule involved in the biochemical interactions (HSP - heat shock protein; oxysterol is an intracellular ligand; RXR - retinoid X receptor).