|Figure 5: Molecular Interaction Map of the pathways upstream of the TFs TCF7L2, SMAD4, AP1,
TP53, E2F:DP1, involved in the control of G0-G1-S genes transcription (MYC and CCND1
genes as examples). A light yellow oval surrounded the cartouches of mutated/altered
signaling-proteins in the colorectal HCT116 cancer line. The targeted inhibitors and
their relative targets are indicated. Reproduced from .