Table 1: List of pathways depicted in the MIM.


1. Pathway [ErbB-family receptors – PI3K – PTEN – AKT – ramifications a, b, c, d];
2. Pathway [ErbB-family receptors – Shc – Grb2 – SOS– GAP– KRAS – BRAF – MEK – ERK – AP1 – TFBSAP1, transcription agonist];
3. Pathway [ErbB-family receptors – E-Cadherin (Cadherin/Catenin adhesive complex)];
4. Pathway [ErbB-family receptors – PLC γ – PIP2 – PKC – BRAF – MEK – ERK - AP1– TFBSAP1, transcription agonist]; the terminal parts of pathway 2 and 4 are the same];
5. Pathway [WNT – Frz/LRP5/6 – Dvl – AXIN – APC – GSK3 ββ-catenin – TCF7L2 – TFBSTCF7L2, transcription agonist];
6. Pathway [TGF β-receptors – SMAD2/3 – SMAD4 – TFBSSMAD, transcription antagonist];
7. Pathway [TGF β-receptors – TAK-1 – TAB2 – NLK – TCF7L2 – TFBSTCF7L2 (TCF7L2 binding site), transcription agonist], converging with 8];
8. Pathway [WNT – Frz/LRP5/6 – TAK-1 – TAB2 – NLK – TCF7L2 – TFBSTCF7L2, transcription agonist], converging with 7].
9. Pathway [Integrins – ILK – PIP3 – AKT – ramifications a, b, c, d]
10. Pathway [Integrins – FAK – AKT – ramifications a, b, c, d]
11. Pathway [Integrins – FAK – PI3K – AKT – ramifications a, b, c, d]
12. Pathway [Integrins – FAK – Grb2 –SOS– GAP– KRAS – BRAF – MEK – ERK – AP1 – TFBSAP1, transcription agonist]
13. Pathway [Integrins – FAK – SRC – ramifications e and f]
14. Pathway [ALK – SRC – ramifications e and f]
15. Pathway [ALK – PI3K – ramifications a, b, c, d]
16. Pathway [ALK – PLC γ – PIP2 – PKC – BRAF – MEK – ERK - AP1– TFBSAP1, transcription agonist]
17. Pathway [c-Met – Shc– Grb2 – SOS– GAP– KRAS – BRAF – MEK – ERK – AP1– TFBSAP1, transcription agonist];
18. Pathway [c-Met – PI3K – AKT – ramifications a, b, c, d];
19. Pathway [c-Met – SRC – ramifications e and f];
AKT Ramifications
a. Pathway [AKT - GSK3 β – APC – β-catenin – TCF7L2 – TFBSTCF7L2, transcription agonist]
b. Pathway [AKT – mTOR – p70S6K]
c. Pathway [AKT – MDM2 – TP53 – TFBSTP53, transcription antagonist]
d. Pathway [AKT – P21 – Cyclin (D/E) / CDK (2/4) – pRB – E2F:DP – TFBSE2F:DP, transcription agonist]
SRC Ramification
e. Pathway [SRC – Grb2 – SOS– GAP– KRAS – BRAF – MEK – ERK- AP1 – TFBSAP1, transcription agonist]
f. Pathway [SRC - PI3K – AKT – ramifications a, b, c, d]
List of biochemical interactions / reactions pathways depicted in the MIM (Fig. 5). Reproduced from [ 29 ].