Figure 1: SBP, PPAR-beta/delta and PPAR-beta/delta target genes in the kidney. HFru diet leads to an increase in SBP from the second week in the diet scheme. GW501516 was able to activate PPAR-beta/delta and its target genes PDK4 and CPT1 in the kidney. A: SBP evolution (n=10/group). B: PPAR-beta/delta and its target genes in the kidney (n=5/group). Data are presented as mean ± SD. *, **, *** and **** indicate P<0.05, P<0.01, P<0.001 and P<0.0001, respectively, compared with the SC group; † indicates P<0.05 compared with the SC+GW group; $, $$ and $$$ indicate P<0.05, P<0.01 and P<0.001, respectively, compared with the HFru group.