Figure 3: Inflammatory state in the kidney. GW501516 could rescue the deleterious effects of HFru diet upon the inflammatory state (n=5/group). A: mRNA levels of proinflammatory cytokines in the kidney. B: IκB-α protein expression. C: p-ERK/ERK protein expression. D: p-JNK/JNK protein expression. Data are presented as mean ± SD. * and ** indicate P<0.05 and P<0.01, respectively, compared with the SC group; $, $$ and $$$ indicate P<0.05, P<0.01 and P<0.001, respectively, compared with the HFru group.