D. Arciola^{* *}Correspondence: D. Arciola, Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada, Email:

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1. Description

Antibiotics’ ability to effectively combat drug-resistant bacteria is severely constrained by the hydrophobic nature of drug molecules, which unquestionably hinders its permanence for clinical applications. Drug resistant bacteria pose a serious threat to human civilization. Major strategies to counteract bacterial drug resistance are provided by the antibacterial properties of nanomaterial’s. In the current study, antibiotic molecules are enclosed in nano-metal organic frameworks to increase their antibacterial efficacy against model drug-resistant bacteria and bacterial biofilm. By using a straightforward synthetic process, we were able to incorporate the well-researched antituberculosis medication Rifampicin (RF), which has significant pharmacological importance, into the pore surface of Zeolitic Imidazolate Framework 8 (ZIF8). The X-Ray Diffraction (XRD) technique has been used to evaluate the synthesised ZIF8 both before and after drug encapsulation. The binding between ZIF8 and RF was studied using electron microscopic techniques such as scanning and transmission electron microscope techniques. Also, we have used picosecond resolved fluorescence spectroscopy to confirm that the ZIF8-RF NanoHybrids (NHs) were generated. The medication release profile experiment proves that ZIF8-RF represents pH-responsive drug delivery and is the best choice for attacking bacterial disease due to its naturally acidic nature. Most astonishingly, ZIF8-RF causes complete destruction of structurally robust bacterial biofilms and increases antibacterial action against methicillin resistant Staphylococcus aureus germs.

Overall, the study provides a thorough physical understanding of synthetic antibiotic encapsulated NHs with outstanding antibacterial activity that can be used in a variety of real world applications. Antibiotic resistance denotes the considerable persistence of microorganisms that can flourish when one or more antibiotics are present. Bacterial multidrug resistance poses a serious threat to human civilization and is developing more quickly as a result of the inappropriate and frequent use of antibiotics. In the future, the absence of efficient antibiotics will make common diseases like bacterial pneumonia and complex treatments like open heart surgery far more risky and potentially fatal. Antibiotic overuse, prolonged course of therapy, and use of doses below therapeutic, prophylactic use of antibiotics and improper use of antibiotics for various non-bacterial disorders limit their usefulness, which is followed by the development of resistance. In order to battle bacterial infections, it is required to design a novel alternative strategy that is targeted and stimulus sensitive. The enduring superbugs demonstrate the onset of the post-antibiotic era and pose a serious threat to human health on a global scale. In the United States, there are more than 2 million patients with serious illnesses, and each year, over 20,000 people lose away due to an infection brought on by bacteria that are safe for antibiotics. According to current predictions, bacterial pollution will cause 10 million deaths annually by 2050. Despite the rigid hygiene standards enforced in medical clinic settings.

The most serious diseases, which are typically referred to as Healthcare Associated Infections (HAIs), are produced in emergency rooms and other settings involving human services. Gram positive bacteria including infections with Staphylococcus aureus and epidermidis are frequently linked to HAIs. The drugresistant strain comes in at number five out of 11 on the list of the most harmful germs to civilization. Alternative antimicrobial treatment is one of the most innovative and encouraging approaches, in our opinion. The usage of stimuli-responsive Nano Hybrids (NHs), which can be responsible for its multifunctionality, multiuse, and remarkably successful execution, is called for as a means of improvement.

Nowadays, Nano-Particles (NPs) are being employed more and more to target microbes and potentially replace natural antibacterial agents. A NH that is potent enough to stop the development of germs in people could increase the viability of antibacterial capacity. The NH will likely maintain stability against degradation while enhancing bioavailability and intracellular movement.